Background: LINC01492 polymorphism has been implicated in the susceptibility of large artery atherosclerotic stroke; however, there is currently a lack of systematic research investigating this association in the Asian population.
Methods: The study enrolled Han Chinese patients with LAA stroke (n=428) and age- and sex-matched controls(n=434). We employed dominant, recessive, and co-dominant genetic models to analyze the distribution of alleles and genotypes for 14 tag single nucleotide polymorphisms in LINC01492. Furthermore, we quantified the transcript levels of LINC01492 as well as concentrations of inflammatory factors (TNFα, IL-1β, IL-6, IL-8, IL-10, IL-18, and CCL18). Additionally, we explored the association between these single nucleotide polymorphisms and levels of inflammatory factors.
Results: The rs10990654 AA genotype of LINC01492 was significantly associated with an increased risk of LAA stroke (OR = 6.403, 95% CI = 1.180-34.734, P = 0.031). Conversely, both the GG genotype of rs10990654 (OR = 0.614, 95% CI = 0.384-0.980, P = 0.041) and the GG genotype of rs16922693 (OR = 0.518, 95% CI= 0.313-0.857, P= 0.010) were found to be associated with a reduced risk in this study population. Additionally, the transcription level of LINC01492 was significantly lower in patients compared to controls. Furthermore, significant variations were observed in IL-10 and IL-18 levels across genotypes at LINC01492 polymorphism loci among patients.
Conclusions: The genetic polymorphisms and transcript levels of LINC01492 exhibit an association with susceptibility to LAA stroke, and the available evidence suggests that this association may be mediated through IL-10 and IL-18.