Background and aims: Multimorbidity (MM) is increasingly common and predicts adverse outcomes, but its influence on recovery from intracerebral haemorrhage (ICH) has not been well established. We assessed the relationship between MM and functional recovery in the third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3).
Methods: Post hoc analysis of the INTERACT3 trial involving 7036 ICH patients randomly allocated to care bundle group (The care bundle included the early intensive lowering of SBP, strict glucose control, antipyretic treatment and rapid reversal of warfarin-related anticoagulation within 1 h of treatment) versus usual care group. Associations of MM (≥2 coexisting chronic diseases) and efficacy outcomes at 6 months were assessed in logistic regression models, including ordinal modified Rankin scale [mRS] scores, major disability (mRS 3-5) and death.
Results: Overall, 7036 ICH patients (mean age 62 years, 36% female) were included. We found significant association of MM and efficacy outcome for ordinal mRS (aOR 1.13, 95%CI 1.03-1.04, p=0.011), and major disability (aOR 1.17, 95%CI 1.03-1.31, p=0.013). But no significant association was found between MM and death (aOR 1.10, 95%CI 0.94-1.29, p=0.229).
Conclusions: MM increases the odds of worse functional outcome but not for death in ICH patients.