Background: The platelet aggregation function is identified as a potential indicator for predicting the prognosis of patients with acute ischemic stroke (AIS). Despite this, there is a lack of study to explore the association between platelet aggregation function within 24h of reperfusion therapy and prognosis of AIS patients.
Methods: This prospective, observational cohort study was conducted at a single center with 67 AIS patients enrolled between November 2018 and December 2020. The maximal platelet aggregation rate (MPA) representing platelet aggregation function, was evaluated by light transimission aggregometry at 0h, 6h, 12h, 18h, and 24h post-reperfusion therapy. The primary outcome was good outcome defined a modified Rankin Scale score (mRS) 0-2) at 90d. Second outcomes comprised neurological function improvement (NFI) at 24h (NIHSS ≤1 point or reduction ≥4 points), symptomatic intracerebral hemorrhage (sICH), and death within 90d.
Results: Influential factors for platelet function aggregation in AIS patients were identified as hypertension, diabetes, smoking, platelet count, D-dimer, triglyceride levels, puncture to arterial opening time (PTR), and TOAST classification, and, with variations among different reperfusion therapy groups. The platelet aggregation function continues to decrease within 0-6h post-treatment and gradually increased thereafter. There was no significant correlation between platelet aggregation function within 24h following reperfusion therapy and clinical outcomes in the groups.
Conclusion: A dynamic change and influential factors of platelet aggregation function were observed within 24h after reperfusion therapy in AIS patients, while the platelet aggregation function was not associated with the prognosis of AIS patients.